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12/23/2024 09:05:18 am

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Gene Test Could Predict Re-occurrence of Breast Tumors

Metastatic Breast Cancer in Pleural Fluid

(Photo : Creative Commons: Flickr)

A new genetic test might help predict the odds of breast tumors re-occurring among women who have had these tumors surgically removed.

This gene test called "Oncotype DX" might add some information to the decision-making process.

The Oncotype test analyzes specific cancer-linked genes to see how active they are. It grades the results on a score between 0 and 100. Dr. Eileen Rakovitch, lead researcher on the new study said the test has been validated using tumor samples from patients in a clinical trial.

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These genetic tests are designed to look for abnormalities and mutations of certain genes such as BRCA1 and BRCA2. They're recommended for individuals with a family history of cancer.

Undergoing these procedures may provide doctors with an insight as to whether there's a harmful mutation in any of these genes. This will give them a heads up if they may progress to cancerous tumors.

In the event a mutation found, a number of options are offered by medical professionals so they can manage and control their risks of developing cancer.

Dr. Len Lichtenfeld, deputy chief medical officer for the American Cancer Society, noted, however, that the ultimate value of the test remains unknown despite the test being on the market.

The new study concentrated on women with ductal carcinoma in situ or abnormal cells in the lining of the milk ducts. These cells could evolve into cancer of the surrounding breast tissue.

Surgery is a usual option to remove these cells because there's no way of foretelling a progression. This surgery is often followed by radiation therapy.

"But we'd all like to have a way to identify women who can avoid further treatment, and those who should have it," said Dr. Lichtenfeld, who was not involved in the study.

Dr. Lichtenfeld pointed out doctors consider factors that affect a woman's need for further treatment such as age and the "grade" of the cancer, or a measure of how aggressive it seems.

He said "the test looks interesting, but it's not widely accepted as a way to guide treatment."

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