The three candidates in contention for U.S. presidency in the 2016 elections have reacted to the tragic mass shooting at an Orlando gay bar that killed 50 people and injured several others.

A gunman opened fire at patrons at a gay club called Pules in Orlando early Sunday morning. The shooting claimed 50 lives and injured 53 others, making it the worst mass shooting in U.S. history.

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The gunman, identified as U.S. citizen Omar Mateen, was reportedly radicalized by the militant group ISIS. The 29-year-old, who was armed with an assault rifle and a handgun, was fatally shot on the scene.

In the wake of the tragic incident, Donald Trump, Bernie Sanders and Hillary Clinton took to social media to comment on the shooting.

Clinton wrote on Twitter that she was devastated by the news of the shooting and that her thoughts and prayers were with those affected by the "horrific act."

Presumptive Democratic nominee later released a lengthier statement on the attack, calling it an "act of terror" and an "act of hate."

"For now, we can say for certain that we need to redouble our efforts to defend our country from threats at home and abroad," the statement read. "That means defeating international terror groups, working with allies and partners to go after them wherever they are, countering their attempts to recruit people here and everywhere, and hardening our defenses at home."

She also voiced her support for the LGBT community and noted

Clinton noted that guns like the one used by the attacker should be kept out of the hands of terrorists and other violent criminals.

GOP presumptive nominee, Trump, also took to Twitter to say the following: "Really bad shooting in Orlando. Police investigating possible terrorism. Many people dead and wounded."

Trump followed up his post with another tweet, saying that he was praying for the victims and their families. "When will this stop? When will we get tough, smart & vigilant?" he asked.

He later released another statement denouncing President Barack Obama for refusing to say the words "radical Islam." He also said that if people won't get "tough and smart real fast," Americans will lose their country. The presumptive Republican nominee also reiterated his stance on immigrants, adding that they have been implicated in terrorism.

Following suit, Vermont senator Bernie Sanders released a statement of his own. "Our thoughts are with the injured and the entire Orlando LGBTQ community," he said.

The presidential candidate addressed the shooting during his Meet The Press appearance later, stating that the shooting was unthinkable and that the U.S. should do everything in its power to prevent guns from falling into the "hands of people who should not have them."

The Orlando shooting comes a day after The Voice contestant Christina Grimmie was fatally shot by a supposed stalker during a meet and greet after her concert.

Also, a day after the deadliest mas shooting in U.S. history, a man planning an attack on the Gay Pride parade in Los Angeles was arrested in Santa Monica after officials allegedly found weapons in his car.

Tags2016 presidential elections, United States, Orlando mass shooting, gay pride, gay club, pulse, Orlando, Orlando shooting, Omar Mateen, Pulse gay