A new study suggests the feared Zika virus that causes deformities in unborn babies might persist in our eyes.

Researchers have found the Zika virus can live in eyes. They've also identified genetic material from the virus in tears, according to a study from Washington University School of Medicine in St. Louis.

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Eye infection raises the possibility people might acquire Zika infection through contact with tears from infected people.

The study helps explain why some Zika patients develop eye disease including a condition known as "uveitis," which can lead to permanent vision loss. The study, in mice, was published Sept. 6 in Cell Reports. It describes the effect of Zika virus infection in the eyes of mouse fetuses, newborns and adults.

Researchers now are planning complementary studies in human patients infected with the virus.

"Our study suggests that the eye could be a reservoir for Zika virus," said Michael Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine and one of the study's senior authors.

"We need to consider whether people with Zika have infectious virus in their eyes and how long it actually persists."

Zika virus causes mild disease in most adults but can cause brain damage and death in fetuses. About a third of all babies infected in utero with Zika show eye disease such as inflammation of the optic nerve, retinal damage or blindness after birth.

In adults, Zika can cause conjunctivitis (redness and itchiness of the eyes) and, in rare cases, uveitis.

To determine what effect Zika infection has on the eye, researchers infected adult mice under the skin -- similar to the way humans are infected by mosquitoes -- and found live virus in the eyes seven days later.

These observations confirm Zika is able to travel to the eye. It's not yet known if the virus typically makes that trip by crossing the blood-retina barrier that separates the eye from the bloodstream, traveling along the optic nerve that connects the brain and the eye, or some other route.

The researchers found the tears of infected mice contained Zika's RNA, the genetic material from the virus, but not infectious virus when tested 28 days after infection.

"Even though we didn't find live virus in mouse tears, that doesn't mean that it couldn't be infectious in humans," said Jonathan Miner, MD, PhD, an instructor in medicine and the study's lead author.

"There could be a window of time when tears are highly infectious and people are coming in contact with it and able to spread it."

The eye is an "immune privileged site," meaning the immune system is less active there, to avoid accidentally damaging sensitive tissues responsible for vision in the process of fighting infection. Consequently, infections sometimes persist in the eye after they have been cleared from the rest of the body.

"We are planning studies in people to find out whether infectious virus persists in the cornea or other compartments of the eye, because that would have implications for corneal transplantation," said Rajendra Apte, MD, PhD, the Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Science, and the study's other senior author.

Other blood-borne viruses such as herpes simplex virus have been transmitted accidentally through corneal transplants.

Zika researchers are increasingly considering alternative routes of transmission because the virus is spreading more quickly than would be expected by mosquito-borne transmission alone.

Even if human tears do not turn out to be infectious, the researchers' detection of live virus in the eye and viral RNA in tears still has practical benefits. Human tears potentially could be tested for viral RNA or antibodies, a less painful way to diagnose recent Zika infection than drawing blood. The mouse eye could be used to test anti-Zika drugs.

TagsZika virus, Eyes, Eye infection, Washington University School of Medicine, uveitis