Mind-body interventions (MBIs) such as meditation, yoga and Tai Chi don't simply relax us. They can 'reverse' the molecular reactions in our DNA that cause ill-health and depression, according to a study by the University of Coventry in the United Kingdom and the University of Radboud in The Netherlands.

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The research reviews over a decade of studies analyzing how the behavior of our genes is affected by different MBIs including mindfulness and yoga. It was published  in the journal, Frontiers in Immunology.

When examined together, the 18 studies that involved 846 participants over 11 years reveal a pattern in the molecular changes which happen to the body as a result of MBIs, and how those changes benefit our mental and physical health.

Researchers focused on how gene expression is affected. This means they looked at the way that genes activate to produce proteins which influence the biological make-up of the body, the brain and the immune system.

When a person is exposed to a stressful event, their sympathetic nervous system (SNS) -- the system responsible for the fight-or-flight response -- is triggered. In turn, this increases the production of a molecule called nuclear factor kappa B (NF-kB), which regulates how our genes are expressed.

NF-kB translates stress by activating genes to produce proteins called cytokines that cause inflammation at cellular level. This reaction is useful as a short-lived fight-or-flight reaction, but if persistent leads to a higher risk of cancer, accelerated aging and psychiatric disorders like depression.

People who practice MBIs exhibit the opposite effect - namely, a decrease in production of NF-kB and cytokines. This event leads to a reversal of the pro-inflammatory gene expression pattern and a reduction in the risk of inflammation-related diseases and conditions.

The study's authors say the inflammatory effect of the fight-or-flight response, which also serves to temporarily bolster the immune system, would have played an important role in mankind's hunter-gatherer prehistory when there was a higher risk of infection from wounds.

In today's society, however, where stress is increasingly psychological and often longer-term, pro-inflammatory gene expression can be persistent and, therefore, more likely to cause psychiatric and medical problems.

"Millions of people around the world already enjoy the health benefits of mind-body interventions like yoga or meditation, but what they perhaps don't realize is that these benefits begin at a molecular level and can change the way our genetic code goes about its business," said lead investigator Ivana Buric from the Brain, Belief and Behavior Lab in Coventry University's Center for Psychology, Behavior and Achievement.

"These activities are leaving what we call a molecular signature in our cells, which reverses the effect that stress or anxiety would have on the body by changing how our genes are expressed. Put simply, MBIs cause the brain to steer our DNA processes along a path which improves our wellbeing.

"More needs to be done to understand these effects in greater depth, for example how they compare with other healthy interventions like exercise or nutrition. But this is an important foundation to build on to help future researchers explore the benefits of increasingly popular mind-body activities."

TagsMind-body interventions, MBIs, Meditation, Yoga, Tai Chi, University of Coventry, University of Radboud, nuclear factor kappa B (NF-kB), Ivana Buric